Human mast cells (MCs) contain TG-rich cytoplasmic lipid droplets (LDs) Sweaters with high arachidonic acid (AA) content.Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for eicosanoid generation by activated human primary MCs in culture.Silencing of ATGL in MCs by siR

Introduction:.Postoperative pancreatic fistula (POPF) is the most dreaded complication after distal pancreatectomy (DP).This multicenter randomized trial evaluated the efficacy, safety, and tolerance of Hemopatch in preventing clinically relevant (grades B/C according to the ISGPS classification) POPF after DP.Material and methods:.After stump clos

Abstract The molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear.DNA sequencing studies have revealed a massive Puzzles mutational burden but have yet to illuminate mechanisms of disease pro

Lifestyle The mammalian intestinal epithelial stem cell (IESC) niche is comprised of diverse epithelial, immune, and stromal cells, which together respond to environmental changes within the lumen and exert coordinated regulation of IESC behavior.There is growing appreciation for the role of the gut microbiota in modulating intestinal proliferation

The history of air masses is often investigated using backward trajectories to gain knowledge about processes along the air parcel path as well as possible source regions.Here, we describe a refined approach that incorporates airborne gas, aerosol, and environmental data into back trajectories and show how this technique allows for simultaneous eva